Molecular Screening Shared Resource

Delivering High Throughput Screening to the UCLA Research Community

High-Throughput Screening | Drug Discovery | Functional Genomics

The MSSR has automated equipment and data collection that make it possible to test about 30,000 compounds (or more) on a system of interest in about a day

Molecular Screening Shared Resource

The MSSR provides a comprehensive range of high-throughput screening (HTS) services including chemical genomics, functional genomics, and drug discovery.

Molecular Screening Shared Resource

Delivering High Throughput Screening to the UCLA research community

The MSSR is a core facility open to all research labs on campus.

The services provided include the use of high throughput screening (HTS) technology, a total of roughly 200,000 compounds in various libraries, siRNA sets of the druggable genome for mouse and human and a database of results from screens. Please use the links above to find out more about the MSSR.

The MSSR is currently funded by the JCCC, the Department of Molecular and Medical Pharmacology, the Department of Microbiology, Immunology and Molecular Genetics, and the Dean’s office, David Geffen School of Medicine and the California NanoSystems Institute.

Contact Information:
Robert Damoiseaux, Director
Phone: (310) 794-1974

Scientific Advisors
Owen Witte, MD
Jing Huang, PhD

The MSSR is located at 2145 California (N)anoSystems Institute (CNSI).

Center Highlights

  • High-Throughput-Screening
  • Drug Discovery
  • Functional Genomics & Novel Applications
  • User base includes: Small BioTech, Big Pharma, Academics, NIH
  • Chemical Libraries: 180,000 compounds of drug-like molecules with emphasis on desirable target classes such as kinases, proteases, phosphatases, GPCRs and ion channel
  • cDNA overexpression library of 16,000 clones accessible as "expression-ready" sets
  • Plater reader based readouts and high content screening

Work performed at the MSSR has supported numerous publications in top notch journals such as Nature Biotechnology, Science, PNAS, amongst others